Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

Deane M Nason; Steven D Heck; Mathew S Bodenstein; John A Lowe 3rd; Robert B Nelson; Dane R Liston; Charles E Nolan; Lorraine F Lanyon; Karen M Ward; Robert A Volkmann

doi:10.1016/j.bmcl.2004.06.043

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4511-4. doi: 10.1016/j.bmcl.2004.06.043.

Authors

Deane M Nason¹, Steven D Heck, Mathew S Bodenstein, John A Lowe 3rd, Robert B Nelson, Dane R Liston, Charles E Nolan, Lorraine F Lanyon, Karen M Ward, Robert A Volkmann

Affiliation

¹ Pfizer Global Research and Development, Groton, CT 06340, USA.

PMID: 15357982
DOI: 10.1016/j.bmcl.2004.06.043

Abstract

The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1-8 are described. These compounds are potent inhibitors of the human nNOS isoform.

MeSH terms

Amines / chemistry*
Amines / pharmacology
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Humans
Nerve Tissue Proteins / antagonists & inhibitors*
Neural Inhibition / drug effects
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase Type I
Pyridines / chemistry*
Pyridines / pharmacology

Substances

Amines
Enzyme Inhibitors
Nerve Tissue Proteins
Pyridines
NOS1 protein, human
Nitric Oxide Synthase
Nitric Oxide Synthase Type I